Assay Detail
Binding
CHEMBL846288
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Inhibition of phosphodiesterase type IV (PDE4) activity
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Orally active indole N-oxide PDE4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.44 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42126 | PICLAMILAST | 2.0 | 1 | 9.00 |
| CHEMBL102635 | — | — | 1 | 8.39 |
| CHEMBL101479 | — | — | 1 | 8.15 |
| CHEMBL102741 | — | — | 1 | 8.10 |
| CHEMBL103007 | — | — | 1 | 7.92 |
| CHEMBL414417 | — | — | 1 | 7.85 |
| CHEMBL323132 | — | — | 1 | 7.80 |
| CHEMBL301201 | — | — | 1 | 7.75 |
| CHEMBL102310 | — | — | 1 | 7.72 |
| CHEMBL102503 | — | — | 1 | 7.70 |
| CHEMBL323069 | — | — | 1 | 7.66 |
| CHEMBL102758 | — | — | 1 | 7.62 |
| CHEMBL318586 | — | — | 1 | 7.52 |
| CHEMBL102876 | — | — | 1 | 7.42 |
| CHEMBL262269 | — | — | 1 | 7.34 |
| CHEMBL322837 | — | — | 1 | 7.10 |
| CHEMBL299332 | — | — | 1 | 7.00 |
| CHEMBL101368 | — | — | 1 | 6.58 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 6.50 |
| CHEMBL321760 | — | — | 1 | 6.38 |
| CHEMBL104780 | — | — | 1 | 6.30 |
| CHEMBL102020 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42126 | PICLAMILAST | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL102635 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL101479 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL102741 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL103007 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL414417 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL323132 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL301201 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL102310 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL102503 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL323069 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL102758 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL318586 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL102876 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL262269 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL322837 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL299332 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL101368 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL321760 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL104780 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL102020 | — | IC50 | = | 1400.0 | nM | 5.85 |