Assay Detail
Functional
CHEMBL846556
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Inhibition of proliferation of v-Ha-ras-transformed RAT1 cells on poly-(HEMA)-coated plates
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Rat1 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Imidazole-containing diarylether and diarylsulfone inhibitors of farnesyl-protein transferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.31 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109303 | — | — | 1 | 7.80 |
| CHEMBL114086 | — | — | 1 | 7.55 |
| CHEMBL112940 | — | — | 1 | 7.51 |
| CHEMBL112324 | — | — | 1 | 6.96 |
| CHEMBL109418 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109303 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL114086 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL112940 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL112324 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL109418 | — | IC50 | = | 177.0 | nM | 6.75 |