Assay Detail
Binding
CHEMBL846805
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Inhibition of crude cGMP phosphodiesterase from canine thoracic aorta
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Tissue | Thoracic aorta |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel compounds possessing potent cAMP and cGMP phosphodiesterase inhibitory activity. Synthesis and cardiovascular effects of a series of imidazo[1,2-a]quinoxalinones and imidazo[1,5-a]quinoxalinones and their aza analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.05 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL330540 | — | — | 1 | 6.52 |
| CHEMBL91789 | — | — | 1 | 6.40 |
| CHEMBL420615 | — | — | 1 | 6.05 |
| CHEMBL90068 | — | — | 1 | 5.52 |
| CHEMBL90932 | — | — | 1 | 5.52 |
| CHEMBL92555 | — | — | 1 | 5.40 |
| CHEMBL90929 | — | — | 1 | 5.30 |
| CHEMBL92216 | — | — | 1 | 5.16 |
| CHEMBL88794 | — | — | 1 | 4.89 |
| CHEMBL93452 | — | — | 1 | 4.85 |
| CHEMBL327854 | — | — | 1 | 4.77 |
| CHEMBL90931 | — | — | 1 | 4.72 |
| CHEMBL92009 | — | — | 1 | 4.62 |
| CHEMBL443233 | — | — | 1 | 4.57 |
| CHEMBL312971 | — | — | 1 | 4.57 |
| CHEMBL275084 | ISOBUTYLMETHYLXANTHINE | — | 1 | 4.55 |
| CHEMBL88818 | — | — | 1 | 4.44 |
| CHEMBL316356 | — | — | 1 | 4.42 |
| CHEMBL88763 | — | — | 1 | 4.41 |
| CHEMBL554030 | — | — | 1 | 4.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL330540 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL91789 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL420615 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL90068 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL90932 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL92555 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL90929 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL92216 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL88794 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL93452 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL327854 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL90931 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL92009 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL443233 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL312971 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL275084 | ISOBUTYLMETHYLXANTHINE | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL88818 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL316356 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL88763 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL554030 | — | IC50 | = | 44000.0 | nM | 4.36 |