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Assay Detail

CHEMBL846925

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Functional
Inhibition cGMP hydrolysis by human platelet phosphodiesterase
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-ones--inhibitors of blood platelet cAMP phosphodiesterase and induced aggregation.
Meanwell NA, Roth HR, Smith EC, Wedding DL, Wright JJ, Fleming JS, Gillespie E.
J Med Chem (1991) 34 : 2906 -2916
PubMed 1654430 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 4.48 5.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL98208 1 5.22
CHEMBL100676 1 4.30
CHEMBL98268 1 4.22
CHEMBL98269 1 4.16
CHEMBL98164 1 -
CHEMBL319947 1 -
CHEMBL99760 1 -
CHEMBL97922 1 -
CHEMBL317399 1 -
CHEMBL98373 1 -
CHEMBL100784 1 -
CHEMBL98812 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL98208 IC50 = 6000.0 nM 5.22
CHEMBL100676 IC50 = 50000.0 nM 4.30
CHEMBL98268 IC50 = 60000.0 nM 4.22
CHEMBL98269 IC50 = 70000.0 nM 4.16
CHEMBL98164 IC50 > 100000.0 nM -
CHEMBL319947 IC50 > 100000.0 nM -
CHEMBL99760 IC50 > 100000.0 nM -
CHEMBL97922 IC50 > 100000.0 nM -
CHEMBL317399 IC50 > 100000.0 nM -
CHEMBL98373 IC50 > 100000.0 nM -
CHEMBL100784 IC50 > 100000.0 nM -
CHEMBL98812 IC50 > 100000.0 nM -