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Assay Detail

CHEMBL846958

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Binding
Compound was evaluated for the inhibition constant against human phosphomannose isomerase (huPMI)
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Mannose-6-phosphate isomerase (CHEMBL2758)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Exploring structure-activity relationships around the phosphomannose isomerase inhibitor AF14049 via combinatorial synthesis.
Bhandari A, Jones DG, Schullek JR, Vo K, Schunk CA, Tamanaha LL, Chen D, Yuan Z, Needels MC, Gallop MA.
Bioorg Med Chem Lett (1998) 8 : 2303 -2308
PubMed 9873532 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 4.58 4.58

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL419459 1 4.58

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL419459 Ki = 26000.0 nM 4.58