Assay Detail
Binding
CHEMBL851371
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DSAC inhibitory potency obtained by the conversion of [32P]-ATP to [32P]-cAMP
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Conformational analysis and molecular modeling of 1-phenyl-, 4-phenyl-, and 1-benzyl-1,2,3,4-tetrahydroisoquinolines as D1 dopamine receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.35 | 9.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | — | 1 | 9.33 |
| CHEMBL64117 | — | — | 1 | 8.20 |
| CHEMBL303993 | — | — | 1 | 8.18 |
| CHEMBL302393 | — | — | 1 | 6.99 |
| CHEMBL65397 | — | — | 1 | 6.96 |
| CHEMBL293828 | — | — | 1 | 6.69 |
| CHEMBL293158 | — | — | 1 | 6.25 |
| CHEMBL59603 | — | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | Ki | = | 0.4677 | nM | 9.33 |
| CHEMBL64117 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL303993 | — | Ki | = | 6.607 | nM | 8.18 |
| CHEMBL302393 | — | Ki | = | 102.33 | nM | 6.99 |
| CHEMBL65397 | — | Ki | = | 109.65 | nM | 6.96 |
| CHEMBL293828 | — | Ki | = | 204.17 | nM | 6.69 |
| CHEMBL293158 | — | Ki | = | 562.34 | nM | 6.25 |
| CHEMBL59603 | — | Ki | = | 630.96 | nM | 6.20 |