Assay Detail
Binding
CHEMBL852180
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Receptor binding affinity for recombinant human N/OFQ peptide receptor (NOP) expressed in chinese hamster ovary cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
N- and C-terminal modifications of nociceptin/orphanin FQ generate highly potent NOP receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 10.17 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL442297 | — | — | 1 | 10.70 |
| CHEMBL264846 | — | — | 1 | 10.66 |
| CHEMBL411649 | — | — | 1 | 10.60 |
| CHEMBL262544 | — | — | 1 | 10.50 |
| CHEMBL263588 | — | — | 1 | 10.32 |
| CHEMBL414767 | — | — | 1 | 9.89 |
| CHEMBL410145 | — | — | 1 | 9.89 |
| CHEMBL413944 | — | — | 1 | 9.62 |
| CHEMBL411621 | — | — | 1 | 9.38 |
| CHEMBL410653 | — | — | 1 | - |
| CHEMBL414782 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL442297 | — | Ki | = | 0.01995 | nM | 10.70 |
| CHEMBL264846 | — | Ki | = | 0.02188 | nM | 10.66 |
| CHEMBL411649 | — | Ki | = | 0.02512 | nM | 10.60 |
| CHEMBL262544 | — | Ki | = | 0.03162 | nM | 10.50 |
| CHEMBL263588 | — | Ki | = | 0.04786 | nM | 10.32 |
| CHEMBL414767 | — | Ki | = | 0.1288 | nM | 9.89 |
| CHEMBL410145 | — | Ki | = | 0.1288 | nM | 9.89 |
| CHEMBL413944 | — | Ki | = | 0.2399 | nM | 9.62 |
| CHEMBL411621 | — | Ki | = | 0.4169 | nM | 9.38 |
| CHEMBL410653 | — | Ki | = | 0.006918 | nM | - |
| CHEMBL414782 | — | Ki | = | 0.004786 | nM | - |