Assay Detail
Binding
CHEMBL853015
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Inhibition of cytosolic phospholipase A2-alpha in GLU micelle assay
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Inhibition of cytosolic phospholipase A2alpha: hit to lead optimization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 46 | 5.23 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29838 | — | — | 1 | 7.40 |
| CHEMBL383420 | — | — | 1 | 6.30 |
| CHEMBL372790 | — | — | 1 | 6.10 |
| CHEMBL381471 | — | — | 1 | 6.00 |
| CHEMBL199669 | — | — | 1 | 6.00 |
| CHEMBL380631 | — | — | 1 | 6.00 |
| CHEMBL199533 | — | — | 1 | 5.70 |
| CHEMBL201266 | — | — | 1 | 5.70 |
| CHEMBL199644 | — | — | 1 | 5.70 |
| CHEMBL199751 | — | — | 1 | 5.70 |
| CHEMBL200054 | — | — | 1 | 5.70 |
| CHEMBL201267 | — | — | 1 | 5.70 |
| CHEMBL370113 | — | — | 1 | 5.70 |
| CHEMBL198292 | — | — | 1 | 5.52 |
| CHEMBL201135 | — | — | 1 | 5.52 |
| CHEMBL371226 | — | — | 1 | 5.52 |
| CHEMBL382306 | — | — | 1 | 5.52 |
| CHEMBL370366 | — | — | 1 | 5.40 |
| CHEMBL197759 | — | — | 1 | 5.30 |
| CHEMBL199714 | — | — | 1 | 5.30 |
| CHEMBL201194 | — | — | 1 | 5.22 |
| CHEMBL370799 | — | — | 1 | 5.22 |
| CHEMBL381068 | — | — | 1 | 5.16 |
| CHEMBL202821 | — | — | 1 | 5.10 |
| CHEMBL201647 | — | — | 1 | 4.96 |
| CHEMBL200025 | — | — | 1 | 4.75 |
| CHEMBL381067 | — | — | 1 | 4.70 |
| CHEMBL199867 | — | — | 1 | 4.70 |
| CHEMBL372950 | — | — | 1 | 4.66 |
| CHEMBL382105 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29838 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL383420 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL372790 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL381471 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL199669 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL380631 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL199533 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL201266 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL199644 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL199751 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL200054 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL201267 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL370113 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL382306 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL201135 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL198292 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL371226 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL370366 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL197759 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL199714 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL201194 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL370799 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL381068 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL202821 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL201647 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL200025 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL381067 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL199867 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL372950 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL382105 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL201428 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL425029 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL198592 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL199745 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL383492 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL381114 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL381944 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL203311 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL199979 | — | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL139858 | — | IC50 | = | 160000.0 | nM | - |
| CHEMBL378803 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL199500 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL201535 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL201524 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL199534 | — | IC50 | = | 340000.0 | nM | - |
| CHEMBL371299 | — | IC50 | = | 165000.0 | nM | - |