Assay Detail
Binding
CHEMBL853223
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant 11-beta-HSD1 transfected in intact HEK293 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
11-beta-hydroxysteroid dehydrogenase 1 (CHEMBL4235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The discovery of new 11beta-hydroxysteroid dehydrogenase type 1 inhibitors by common feature pharmacophore modeling and virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.57 | 6.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL211039 | — | — | 1 | 6.39 |
| CHEMBL425772 | — | — | 1 | 5.99 |
| CHEMBL207413 | ACETOXOLONE | -1.0 | 1 | 5.46 |
| CHEMBL382614 | — | — | 1 | 5.42 |
| CHEMBL210465 | — | — | 1 | 5.28 |
| CHEMBL380677 | — | — | 1 | 4.90 |
| CHEMBL206908 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL211039 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL425772 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL207413 | ACETOXOLONE | IC50 | = | 3450.0 | nM | 5.46 |
| CHEMBL382614 | — | IC50 | = | 3840.0 | nM | 5.42 |
| CHEMBL210465 | — | IC50 | = | 5210.0 | nM | 5.28 |
| CHEMBL380677 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL206908 | — | IC50 | > | 50000.0 | nM | - |