Assay Detail
Toxicity
CHEMBL853270
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of hERG potassium channel in HEK293 cells by patch clamp assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.14 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296419 | ASTEMIZOLE | 4.0 | 1 | 9.05 |
| CHEMBL210537 | — | — | 1 | 6.52 |
| CHEMBL377697 | — | — | 1 | 5.82 |
| CHEMBL211012 | — | — | 1 | 5.70 |
| CHEMBL207478 | — | — | 1 | 5.66 |
| CHEMBL379984 | — | — | 1 | 5.52 |
| CHEMBL209821 | NALUZOTAN | 3.0 | 1 | 5.42 |
| CHEMBL207220 | — | — | 1 | 5.40 |
| CHEMBL209324 | — | — | 1 | - |
| CHEMBL411941 | CYCLORGDFV | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296419 | ASTEMIZOLE | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL210537 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL377697 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL211012 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL207478 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL379984 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL209821 | NALUZOTAN | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL207220 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL209324 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL411941 | CYCLORGDFV | IC50 | - | — | - |