Assay Detail
Binding
CHEMBL853453
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of radiolabeled NalBzOH from kappa3 opioid receptor in Hartley guinea pig brain
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 7.02 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL378753 | — | — | 1 | 9.52 |
| CHEMBL214040 | — | — | 1 | 8.26 |
| CHEMBL1418 | — | — | 1 | 8.20 |
| CHEMBL385448 | — | — | 1 | 8.15 |
| CHEMBL213228 | — | — | 1 | 7.95 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 7.86 |
| CHEMBL385048 | — | — | 1 | 7.70 |
| CHEMBL38874 | DAMGO | — | 1 | 7.57 |
| CHEMBL211576 | — | — | 1 | 6.58 |
| CHEMBL13786 | — | — | 1 | 6.56 |
| CHEMBL379928 | — | — | 1 | 6.40 |
| CHEMBL1417 | — | — | 1 | 6.34 |
| CHEMBL209751 | — | — | 1 | 6.29 |
| CHEMBL1416 | — | — | 1 | 6.12 |
| CHEMBL437682 | — | — | 1 | 6.08 |
| CHEMBL213737 | — | — | 1 | 6.08 |
| CHEMBL143939 | — | — | 1 | 5.99 |
| CHEMBL440765 | U-69593 | — | 1 | 5.96 |
| CHEMBL1415 | — | — | 1 | 5.77 |
| CHEMBL211374 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL378753 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL214040 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL1418 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL385448 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL213228 | — | Ki | = | 11.2 | nM | 7.95 |
| CHEMBL70 | MORPHINE | Ki | = | 13.9 | nM | 7.86 |
| CHEMBL385048 | — | Ki | = | 19.9 | nM | 7.70 |
| CHEMBL38874 | DAMGO | Ki | = | 26.9 | nM | 7.57 |
| CHEMBL211576 | — | Ki | = | 266.0 | nM | 6.58 |
| CHEMBL13786 | — | Ki | = | 277.0 | nM | 6.56 |
| CHEMBL379928 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL1417 | — | Ki | = | 455.0 | nM | 6.34 |
| CHEMBL209751 | — | Ki | = | 513.0 | nM | 6.29 |
| CHEMBL1416 | — | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL437682 | — | Ki | = | 838.0 | nM | 6.08 |
| CHEMBL213737 | — | Ki | = | 822.0 | nM | 6.08 |
| CHEMBL143939 | — | Ki | = | 1028.0 | nM | 5.99 |
| CHEMBL440765 | U-69593 | Ki | = | 1099.0 | nM | 5.96 |
| CHEMBL1415 | — | Ki | = | 1694.0 | nM | 5.77 |
| CHEMBL211374 | — | Ki | > | 10000.0 | nM | - |