Assay Detail
Binding
CHEMBL853536
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Inhibition of bovine mitochondrial NADH-ubiquinone oxidoreductase by NADH oxidase assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Expert |
Target
Mitochondrial complex I; NADH oxidoreductase (CHEMBL614865) ↗| Type | PROTEIN COMPLEX |
| Organism | Bos taurus |
Publication
Function of the alkyl side chains of Deltalac-acetogenins in the inhibitory effect on mitochondrial complex I (NADH-ubiquinone oxidoreductase).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.18 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL464549 | dleta-lac-Acetogenin | — | 1 | 8.77 |
| CHEMBL208839 | — | — | 1 | 8.49 |
| CHEMBL209302 | — | — | 1 | 8.12 |
| CHEMBL211108 | — | — | 1 | 8.05 |
| CHEMBL377863 | — | — | 1 | 7.57 |
| CHEMBL377013 | — | — | 1 | 7.47 |
| CHEMBL379529 | — | — | 1 | 7.35 |
| CHEMBL208980 | — | — | 1 | 7.35 |
| CHEMBL211884 | — | — | 1 | 6.55 |
| CHEMBL211178 | — | — | 1 | 6.39 |
| CHEMBL211345 | — | — | 1 | 6.06 |
| CHEMBL378692 | — | — | 1 | 5.82 |
| CHEMBL80354 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL464549 | dleta-lac-Acetogenin | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL208839 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL209302 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL211108 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL377863 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL377013 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL379529 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL208980 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL211884 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL211178 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL211345 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL378692 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL80354 | — | IC50 | = | 4500.0 | nM | 5.35 |