Assay Detail
Functional
CHEMBL853545
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist potency at cloned recombinant human adenosine A2B receptor transfected in CHO cells by cAMP assay
23
Total Activities
23
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and structure-activity relationships of 1-,3-,8-, and 9-substituted-9-deazaxanthines at the human A2B adenosine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| pA2 | 17 | - | - |
| Kd | 6 | 8.19 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL199446 | — | — | 1 | 8.40 |
| CHEMBL201750 | — | — | 1 | 8.30 |
| CHEMBL372148 | — | — | 1 | 8.20 |
| CHEMBL382135 | — | — | 1 | 8.17 |
| CHEMBL370378 | — | — | 1 | 8.06 |
| CHEMBL201721 | — | — | 1 | 8.00 |
| CHEMBL199910 | — | — | 1 | - |
| CHEMBL199717 | — | — | 1 | - |
| CHEMBL201003 | — | — | 1 | - |
| CHEMBL197606 | — | — | 1 | - |
| CHEMBL199808 | — | — | 1 | - |
| CHEMBL203208 | — | — | 1 | - |
| CHEMBL199856 | — | — | 1 | - |
| CHEMBL201608 | — | — | 1 | - |
| CHEMBL203467 | — | — | 1 | - |
| CHEMBL201217 | — | — | 1 | - |
| CHEMBL201228 | — | — | 1 | - |
| CHEMBL201591 | — | — | 1 | - |
| CHEMBL381747 | — | — | 1 | - |
| CHEMBL201578 | — | — | 1 | - |
| CHEMBL201536 | — | — | 1 | - |
| CHEMBL202925 | — | — | 1 | - |
| CHEMBL383031 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL199446 | — | Kd | = | 3.981 | nM | 8.40 |
| CHEMBL201750 | — | Kd | = | 5.012 | nM | 8.30 |
| CHEMBL372148 | — | Kd | = | 6.31 | nM | 8.20 |
| CHEMBL382135 | — | Kd | = | 6.761 | nM | 8.17 |
| CHEMBL370378 | — | Kd | = | 8.71 | nM | 8.06 |
| CHEMBL201721 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL199910 | — | pA2 | - | — | - | |
| CHEMBL199717 | — | pA2 | - | — | - | |
| CHEMBL201003 | — | pA2 | - | — | - | |
| CHEMBL197606 | — | pA2 | - | — | - | |
| CHEMBL199808 | — | pA2 | - | — | - | |
| CHEMBL203208 | — | pA2 | - | — | - | |
| CHEMBL199856 | — | pA2 | - | — | - | |
| CHEMBL201608 | — | pA2 | - | — | - | |
| CHEMBL203467 | — | pA2 | - | — | - | |
| CHEMBL201217 | — | pA2 | - | — | - | |
| CHEMBL201228 | — | pA2 | - | — | - | |
| CHEMBL201591 | — | pA2 | - | — | - | |
| CHEMBL381747 | — | pA2 | - | — | - | |
| CHEMBL201578 | — | pA2 | - | — | - | |
| CHEMBL201536 | — | pA2 | - | — | - | |
| CHEMBL202925 | — | pA2 | - | — | - | |
| CHEMBL383031 | — | pA2 | - | — | - |