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Assay Detail

CHEMBL853567

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of growth of MCF7 cells
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Expert

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

New arylthioindoles: potent inhibitors of tubulin polymerization. 2. Structure-activity relationships and molecular modeling studies.
De Martino G, Edler MC, La Regina G, Coluccia A, Barbera MC, Barrow D, Nicholson RI, Chiosis G, Brancale A, Hamel E, Artico M, Silvestri R.
J Med Chem (2006) 49 : 947 -954
PubMed 16451061 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 31 6.73 7.47

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL201490 1 7.47
CHEMBL202029 1 7.40
CHEMBL381933 1 7.38
CHEMBL203031 1 7.34
CHEMBL381787 1 6.96
CHEMBL380871 1 6.92
CHEMBL373244 1 6.82
CHEMBL380903 1 6.55
CHEMBL203353 1 6.48
CHEMBL382827 1 6.46
CHEMBL200083 1 6.00
CHEMBL372987 1 5.89
CHEMBL201451 1 5.80
CHEMBL372986 1 -
CHEMBL200978 1 -
CHEMBL199392 1 -
CHEMBL200078 1 -
CHEMBL201631 1 -
CHEMBL199747 1 -
CHEMBL201183 1 -
CHEMBL197661 1 -
CHEMBL373208 1 -
CHEMBL381320 1 -
CHEMBL201286 1 -
CHEMBL203412 1 -
CHEMBL373225 1 -
CHEMBL199514 1 -
CHEMBL200062 1 -
CHEMBL383538 1 -
CHEMBL201898 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL201490 IC50 = 34.0 nM 7.47
CHEMBL202029 IC50 = 40.0 nM 7.40
CHEMBL381933 IC50 = 42.0 nM 7.38
CHEMBL203031 IC50 = 46.0 nM 7.34
CHEMBL381787 IC50 = 110.0 nM 6.96
CHEMBL380871 IC50 = 120.0 nM 6.92
CHEMBL373244 IC50 = 150.0 nM 6.82
CHEMBL380903 IC50 = 280.0 nM 6.55
CHEMBL203353 IC50 = 330.0 nM 6.48
CHEMBL382827 IC50 = 350.0 nM 6.46
CHEMBL200083 IC50 = 1000.0 nM 6.00
CHEMBL372987 IC50 = 1300.0 nM 5.89
CHEMBL201451 IC50 = 1600.0 nM 5.80
CHEMBL201740 IC50 > 2.5 nM -
CHEMBL372986 IC50 > 2.5 nM -
CHEMBL200978 IC50 > 2.5 nM -
CHEMBL199392 IC50 > 2.5 nM -
CHEMBL200078 IC50 > 2.5 nM -
CHEMBL201631 IC50 > 2.5 nM -
CHEMBL199747 IC50 > 2.5 nM -
CHEMBL201183 IC50 > 2.5 nM -
CHEMBL197661 IC50 > 2.5 nM -
CHEMBL373208 IC50 > 2.5 nM -
CHEMBL381320 IC50 > 2.5 nM -
CHEMBL201286 IC50 > 2.5 nM -
CHEMBL203412 IC50 > 2.5 nM -
CHEMBL373225 IC50 > 2.5 nM -
CHEMBL199514 IC50 > 2.5 nM -
CHEMBL200062 IC50 > 2.5 nM -
CHEMBL383538 IC50 > 2.5 nM -
CHEMBL201898 IC50 > 2.5 nM -