Assay Detail
Binding
CHEMBL853635
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Inhibitory constant for the inhibition of human Endothelial nitric oxide synthase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Conformationally restricted arginine analogues as inhibitors of human nitric oxide synthase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.66 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL298404 | — | — | 1 | 6.60 |
| CHEMBL49881 | — | — | 1 | 6.57 |
| CHEMBL256147 | TILARGININE | 3.0 | 1 | 6.40 |
| CHEMBL11471 | L-NIO | — | 1 | 6.09 |
| CHEMBL52280 | — | — | 1 | 5.80 |
| CHEMBL48861 | — | — | 1 | 5.06 |
| CHEMBL49010 | — | — | 1 | 4.41 |
| CHEMBL49934 | — | — | 1 | 4.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL298404 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL49881 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL256147 | TILARGININE | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL11471 | L-NIO | Ki | = | 810.0 | nM | 6.09 |
| CHEMBL52280 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL48861 | — | Ki | = | 8800.0 | nM | 5.06 |
| CHEMBL49010 | — | Ki | = | 39000.0 | nM | 4.41 |
| CHEMBL49934 | — | Ki | = | 46000.0 | nM | 4.34 |