Assay Detail
Binding
CHEMBL853846
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]SR-141716 from human CB1 receptor expressed in HEK293 cells
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Biarylpyrazole inverse agonists at the cannabinoid CB1 receptor: importance of the C-3 carboxamide oxygen/lysine3.28(192) interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.64 | 8.74 |
| Kd | 1 | 8.74 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL111 | RIMONABANT | 4.0 | 1 | 8.74 |
| CHEMBL15874 | — | — | 1 | 8.74 |
| CHEMBL385768 | — | — | 1 | 7.77 |
| CHEMBL15478 | — | — | 1 | 7.52 |
| CHEMBL386832 | — | — | 1 | 7.50 |
| CHEMBL385964 | — | — | 1 | 6.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL111 | RIMONABANT | Kd | = | 1.8 | nM | 8.74 |
| CHEMBL15874 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL385768 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL15478 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL386832 | — | Ki | = | 31.3 | nM | 7.50 |
| CHEMBL385964 | — | Ki | = | 213.0 | nM | 6.67 |