Assay Detail
Functional
CHEMBL853877
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of SK-HEP-1 cells by crystal violet assay after 24 hrs
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-HEP1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and preliminary evaluation of doxazolidine carbamates as prodrugs activated by carboxylesterases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.44 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.30 |
| CHEMBL384221 | — | — | 1 | 6.70 |
| CHEMBL214810 | — | — | 1 | 6.40 |
| CHEMBL384220 | — | — | 1 | 6.00 |
| CHEMBL214168 | — | — | 1 | 5.80 |
| CHEMBL383964 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL384221 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL214810 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL384220 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL214168 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL383964 | — | IC50 | < | 1000.0 | nM | - |