Assay Detail
Functional
CHEMBL853926
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JNK2 by ATF2 phosphorylation assay
55
Total Activities
55
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Aminopyridine carboxamides as c-Jun N-terminal kinase inhibitors: targeting the gatekeeper residue and beyond.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 55 | 6.37 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL221227 | — | — | 1 | 7.52 |
| CHEMBL220504 | — | — | 1 | 7.42 |
| CHEMBL374269 | — | — | 1 | 7.33 |
| CHEMBL220658 | — | — | 1 | 7.16 |
| CHEMBL386010 | — | — | 1 | 7.09 |
| CHEMBL218194 | — | — | 1 | 7.08 |
| CHEMBL221315 | — | — | 1 | 7.06 |
| CHEMBL374193 | — | — | 1 | 7.01 |
| CHEMBL384219 | — | — | 1 | 7.00 |
| CHEMBL220812 | — | — | 1 | 6.92 |
| CHEMBL218219 | — | — | 1 | 6.82 |
| CHEMBL221229 | — | — | 1 | 6.80 |
| CHEMBL218367 | — | — | 1 | 6.80 |
| CHEMBL434560 | — | — | 1 | 6.75 |
| CHEMBL384951 | — | — | 1 | 6.68 |
| CHEMBL221126 | — | — | 1 | 6.64 |
| CHEMBL221745 | — | — | 1 | 6.62 |
| CHEMBL218141 | — | — | 1 | 6.62 |
| CHEMBL218657 | — | — | 1 | 6.58 |
| CHEMBL375795 | — | — | 1 | 6.54 |
| CHEMBL383994 | — | — | 1 | 6.52 |
| CHEMBL221128 | — | — | 1 | 6.52 |
| CHEMBL220696 | — | — | 1 | 6.50 |
| CHEMBL220811 | — | — | 1 | 6.47 |
| CHEMBL218658 | — | — | 1 | 6.43 |
| CHEMBL219112 | — | — | 1 | 6.41 |
| CHEMBL434368 | — | — | 1 | 6.37 |
| CHEMBL218419 | — | — | 1 | 6.35 |
| CHEMBL387253 | — | — | 1 | 6.28 |
| CHEMBL221252 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL221227 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL220504 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL374269 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL220658 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL386010 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL218194 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL221315 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL374193 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL384219 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL220812 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL218219 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL221229 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL218367 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL434560 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL384951 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL221126 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL221745 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL218141 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL218657 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL375795 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL383994 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL221128 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL220696 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL220811 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL218658 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL219112 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL434368 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL218419 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL387253 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL221252 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL374431 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL374447 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL220547 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL222008 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL221075 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL221179 | — | IC50 | = | 969.0 | nM | 6.01 |
| CHEMBL220758 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL385177 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL274389 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL221916 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL220865 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL220864 | — | IC50 | = | 4160.0 | nM | 5.38 |
| CHEMBL374795 | — | IC50 | = | 4130.0 | nM | 5.38 |
| CHEMBL373740 | — | IC50 | = | 4320.0 | nM | 5.37 |
| CHEMBL376096 | — | IC50 | = | 4610.0 | nM | 5.34 |
| CHEMBL220749 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL222011 | — | IC50 | = | 6920.0 | nM | 5.16 |
| CHEMBL221175 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL374855 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL221963 | — | IC50 | - | — | - |