Assay Detail
ADMET
CHEMBL853992
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Cytotoxicity against mouse P815 cells after 3 days
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Mus musculus |
| Cell Type | P815 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
DNA interstrand crosslinking agents: synthesis, DNA interactions, and cytotoxicity of dimeric achiral seco-amino-CBI and conjugates of achiral seco-amino-CBI with pyrrolobenzodiazepine (PBD).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.14 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191295 | — | — | 1 | 8.07 |
| CHEMBL221069 | — | — | 1 | 7.58 |
| CHEMBL192069 | CENTANAMYCIN | — | 1 | 7.17 |
| CHEMBL375999 | — | — | 1 | 6.25 |
| CHEMBL427323 | — | — | 1 | 5.25 |
| CHEMBL376224 | — | — | 1 | 4.38 |
| CHEMBL300580 | — | — | 1 | 4.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191295 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL221069 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL192069 | CENTANAMYCIN | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL375999 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL427323 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL376224 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL300580 | — | IC50 | = | 55000.0 | nM | 4.26 |