Assay Detail
Binding
CHEMBL854203
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of gamma secretase
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
3,4-Fused cyclohexyl sulfones as gamma-secretase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 9.43 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL209888 | — | — | 1 | 10.40 |
| CHEMBL377691 | — | — | 1 | 10.22 |
| CHEMBL379089 | — | — | 1 | 10.10 |
| CHEMBL210587 | — | — | 1 | 9.72 |
| CHEMBL427397 | — | — | 1 | 9.62 |
| CHEMBL378502 | — | — | 1 | 9.59 |
| CHEMBL207353 | — | — | 1 | 9.40 |
| CHEMBL207454 | — | — | 1 | 9.39 |
| CHEMBL377264 | — | — | 1 | 9.12 |
| CHEMBL384207 | — | — | 1 | 9.05 |
| CHEMBL377367 | — | — | 1 | 8.93 |
| CHEMBL208089 | — | — | 1 | 8.86 |
| CHEMBL210279 | — | — | 1 | 8.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL209888 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL377691 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL379089 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL210587 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL427397 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL378502 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL207353 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL207454 | — | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL377264 | — | IC50 | = | 0.76 | nM | 9.12 |
| CHEMBL384207 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL377367 | — | IC50 | = | 1.17 | nM | 8.93 |
| CHEMBL208089 | — | IC50 | = | 1.39 | nM | 8.86 |
| CHEMBL210279 | — | IC50 | = | 6.18 | nM | 8.21 |