Assay Detail
Binding
CHEMBL854244
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Binding affinity to human CA2 by ThermoFluor assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Inhibition of carbonic anhydrase-II by sulfamate and sulfamide groups: an investigation involving direct thermodynamic binding measurements.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 5.82 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL417656 | — | — | 1 | 8.00 |
| CHEMBL24259 | PHENYLSULFAMATE | — | 1 | 6.96 |
| CHEMBL180475 | — | — | 1 | 6.85 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 6.54 |
| CHEMBL172215 | — | — | 1 | 5.70 |
| CHEMBL168514 | PHENYLSULFAMIDE | — | 1 | 5.34 |
| CHEMBL175644 | — | — | 1 | 5.00 |
| CHEMBL177425 | — | — | 1 | 4.90 |
| CHEMBL283695 | — | — | 1 | 4.60 |
| CHEMBL378292 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL417656 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL24259 | PHENYLSULFAMATE | Kd | = | 110.0 | nM | 6.96 |
| CHEMBL180475 | — | Kd | = | 140.0 | nM | 6.85 |
| CHEMBL220492 | TOPIRAMATE | Kd | = | 290.0 | nM | 6.54 |
| CHEMBL172215 | — | Kd | = | 2000.0 | nM | 5.70 |
| CHEMBL168514 | PHENYLSULFAMIDE | Kd | = | 4550.0 | nM | 5.34 |
| CHEMBL175644 | — | Kd | = | 10000.0 | nM | 5.00 |
| CHEMBL177425 | — | Kd | = | 12500.0 | nM | 4.90 |
| CHEMBL283695 | — | Kd | = | 25000.0 | nM | 4.60 |
| CHEMBL378292 | — | Kd | = | 50000.0 | nM | 4.30 |