Assay Detail
Functional
CHEMBL854282
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Cytotoxicity against human HPAC cell line
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HPAC |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and evaluation of novel kazusamycin A derivatives as potent antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.32 | 10.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL207218 | — | — | 1 | 10.42 |
| CHEMBL207141 | KAZUSAMYCIN A | — | 1 | 10.13 |
| CHEMBL379283 | — | — | 1 | 9.51 |
| CHEMBL210988 | — | — | 1 | 6.75 |
| CHEMBL210937 | — | — | 1 | 4.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL207218 | — | IC50 | = | 0.0382 | nM | 10.42 |
| CHEMBL207141 | KAZUSAMYCIN A | IC50 | = | 0.0747 | nM | 10.13 |
| CHEMBL379283 | — | IC50 | = | 0.309 | nM | 9.51 |
| CHEMBL210988 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL210937 | — | IC50 | = | 16100.0 | nM | 4.79 |