Assay Detail
Binding
CHEMBL854316
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Displacement of DNSA from CAII in bovine erythrocytes
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of novel benzene sulfonamides with potent binding affinity for bovine carbonic anhydrase II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.00 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL200931 | — | — | 1 | 8.33 |
| CHEMBL199828 | — | — | 1 | 8.31 |
| CHEMBL199364 | — | — | 1 | 8.28 |
| CHEMBL200074 | — | — | 1 | 8.11 |
| CHEMBL381455 | — | — | 1 | 8.07 |
| CHEMBL199368 | — | — | 1 | 8.04 |
| CHEMBL199651 | — | — | 1 | 8.03 |
| CHEMBL414 | CARZENIDE | 2.0 | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL200931 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL199828 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL199364 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL200074 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL381455 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL199368 | — | Ki | = | 9.1 | nM | 8.04 |
| CHEMBL199651 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL414 | CARZENIDE | Ki | = | 151.0 | nM | 6.82 |