Assay Detail
Functional
CHEMBL854458
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Antiproliferative activity against NTR expressing human SKOV3 cells after 18 hrs
10
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and biological evaluation of cyclic and acyclic nitrobenzylphosphoramide mustards for E. coli nitroreductase activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.81 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL144896 | — | — | 1 | 6.80 |
| CHEMBL23330 | TRETAZICAR | 2.0 | 1 | 5.70 |
| CHEMBL375660 | — | — | 2 | 5.68 |
| CHEMBL377628 | — | — | 2 | 5.60 |
| CHEMBL209962 | — | — | 2 | - |
| CHEMBL213994 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL144896 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL23330 | TRETAZICAR | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL375660 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL375660 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL377628 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL377628 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL209962 | — | IC50 | - | — | - | |
| CHEMBL209962 | — | IC50 | - | — | - | |
| CHEMBL213994 | — | IC50 | = | 530000.0 | nM | - |
| CHEMBL213994 | — | IC50 | = | 210000.0 | nM | - |