Assay Detail
Functional
CHEMBL854664
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at PPARbeta/delta by luciferase reporter gene transactivation assay in COS7 cells
12
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor delta (CHEMBL3979) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Studies towards the conception of new selective PPARbeta/delta ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 7.11 | 9.00 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38943 | GW501516 | 2.0 | 1 | 9.00 |
| CHEMBL213355 | — | — | 1 | 8.15 |
| CHEMBL425431 | — | — | 1 | 7.82 |
| CHEMBL214394 | — | — | 1 | 7.80 |
| CHEMBL212993 | — | — | 1 | 7.09 |
| CHEMBL211963 | — | — | 1 | 7.01 |
| CHEMBL153057 | — | — | 1 | 6.90 |
| CHEMBL373785 | — | — | 1 | 6.34 |
| CHEMBL213132 | — | — | 1 | 5.98 |
| CHEMBL212808 | — | — | 1 | 5.00 |
| CHEMBL213411 | — | — | 1 | - |
| CHEMBL213410 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38943 | GW501516 | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL213355 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL425431 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL214394 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL212993 | — | EC50 | = | 82.0 | nM | 7.09 |
| CHEMBL211963 | — | EC50 | = | 98.0 | nM | 7.01 |
| CHEMBL153057 | — | EC50 | = | 125.0 | nM | 6.90 |
| CHEMBL373785 | — | EC50 | = | 457.0 | nM | 6.34 |
| CHEMBL213132 | — | EC50 | = | 1046.0 | nM | 5.98 |
| CHEMBL212808 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL213411 | — | Activity | - | — | - | |
| CHEMBL213410 | — | Activity | - | — | - |