Assay Detail
Functional
CHEMBL854666
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at PPARgamma by luciferase reporter gene transactivation assay in COS7 cells
12
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Studies towards the conception of new selective PPARbeta/delta ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.98 | 6.82 |
| Activity | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL213355 | — | — | 1 | 6.82 |
| CHEMBL373785 | — | — | 1 | 6.54 |
| CHEMBL212993 | — | — | 1 | 6.12 |
| CHEMBL211963 | — | — | 1 | 5.93 |
| CHEMBL214394 | — | — | 1 | 5.90 |
| CHEMBL425431 | — | — | 1 | 5.80 |
| CHEMBL153057 | — | — | 1 | 5.74 |
| CHEMBL38943 | GW501516 | 2.0 | 1 | 5.00 |
| CHEMBL212808 | — | — | 1 | - |
| CHEMBL213411 | — | — | 1 | - |
| CHEMBL213410 | — | — | 1 | - |
| CHEMBL213132 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL213355 | — | EC50 | = | 153.0 | nM | 6.82 |
| CHEMBL373785 | — | EC50 | = | 288.0 | nM | 6.54 |
| CHEMBL212993 | — | EC50 | = | 757.0 | nM | 6.12 |
| CHEMBL211963 | — | EC50 | = | 1185.0 | nM | 5.93 |
| CHEMBL214394 | — | EC50 | = | 1261.0 | nM | 5.90 |
| CHEMBL425431 | — | EC50 | = | 1582.0 | nM | 5.80 |
| CHEMBL153057 | — | EC50 | = | 1824.0 | nM | 5.74 |
| CHEMBL38943 | GW501516 | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL212808 | — | Activity | - | — | - | |
| CHEMBL213411 | — | Activity | - | — | - | |
| CHEMBL213410 | — | Activity | - | — | - | |
| CHEMBL213132 | — | Activity | - | — | - |