Assay Detail
Functional
CHEMBL854671
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist potency at PPARalpha in CV1 cells by cell based transient transfection assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 6.99 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376641 | — | — | 1 | 8.40 |
| CHEMBL219626 | — | — | 1 | 8.40 |
| CHEMBL375760 | — | — | 1 | 8.40 |
| CHEMBL219586 | GW590735 | 2.0 | 1 | 8.40 |
| CHEMBL221074 | — | — | 1 | 8.30 |
| CHEMBL220281 | — | — | 1 | 8.00 |
| CHEMBL218691 | — | — | 1 | 8.00 |
| CHEMBL218637 | — | — | 1 | 7.52 |
| CHEMBL219587 | — | — | 1 | 7.40 |
| CHEMBL218094 | — | — | 1 | 7.16 |
| CHEMBL221201 | — | — | 1 | 6.96 |
| CHEMBL218784 | — | — | 1 | 6.92 |
| CHEMBL218687 | — | — | 1 | 6.68 |
| CHEMBL220926 | — | — | 1 | 6.62 |
| CHEMBL375761 | — | — | 1 | 6.33 |
| CHEMBL221146 | — | — | 1 | 5.88 |
| CHEMBL38943 | GW501516 | 2.0 | 1 | 5.72 |
| CHEMBL218442 | — | — | 1 | 5.72 |
| CHEMBL221755 | — | — | 1 | 5.70 |
| CHEMBL221254 | — | — | 1 | 5.25 |
| CHEMBL374355 | — | — | 1 | 5.02 |
| CHEMBL220751 | — | — | 1 | - |
| CHEMBL376050 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376641 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL219626 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL375760 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL219586 | GW590735 | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL221074 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL220281 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL218691 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL218637 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL219587 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL218094 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL221201 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL218784 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL218687 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL220926 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL375761 | — | EC50 | = | 465.0 | nM | 6.33 |
| CHEMBL221146 | — | EC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL38943 | GW501516 | EC50 | = | 1888.0 | nM | 5.72 |
| CHEMBL218442 | — | EC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL221755 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL221254 | — | EC50 | = | 5640.0 | nM | 5.25 |
| CHEMBL374355 | — | EC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL220751 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL376050 | — | EC50 | > | 10000.0 | nM | - |