Assay Detail
Binding
CHEMBL854881
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Inhibition of binding to serotonin receptor 5HT2C
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel pyrazolopiperazinone- and pyrrolopiperazinone-based MCH-R1 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.01 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216280 | — | — | 1 | 7.00 |
| CHEMBL216242 | — | — | 1 | 6.16 |
| CHEMBL450942 | — | — | 1 | 5.60 |
| CHEMBL217196 | — | — | 1 | 5.28 |
| CHEMBL408198 | — | — | 1 | - |
| CHEMBL217861 | — | — | 1 | - |
| CHEMBL217140 | — | — | 1 | - |
| CHEMBL385340 | — | — | 1 | - |
| CHEMBL217351 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216280 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL216242 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL450942 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL217196 | — | Ki | = | 5300.0 | nM | 5.28 |
| CHEMBL408198 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL217861 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL217140 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL385340 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL217351 | — | Ki | > | 100000.0 | nM | - |