Assay Detail
Binding
CHEMBL854891
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 3H-dofetilide from hERG-expressing HEK membrane homogenates
10
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Constrained 7-fluorocarboxychromone-4-aminopiperidine based Melanin-concentrating hormone receptor 1 antagonists: the effects of chirality on substituted indan-1-ylamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.84 | 5.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL425257 | — | — | 1 | 5.23 |
| CHEMBL214585 | — | — | 3 | 5.10 |
| CHEMBL384919 | — | — | 1 | 4.84 |
| CHEMBL214731 | — | — | 1 | 4.82 |
| CHEMBL215661 | — | — | 3 | 4.81 |
| CHEMBL384111 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL425257 | — | IC50 | = | 5860.0 | nM | 5.23 |
| CHEMBL214585 | — | IC50 | = | 7870.0 | nM | 5.10 |
| CHEMBL214585 | — | IC50 | = | 9310.0 | nM | 5.03 |
| CHEMBL214585 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL384919 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL214731 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL215661 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL384111 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL215661 | — | IC50 | = | 27200.0 | nM | 4.57 |
| CHEMBL215661 | — | IC50 | = | 34800.0 | nM | 4.46 |