Assay Detail
Binding
CHEMBL854892
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of binding to hERG
17
Total Activities
17
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists--Increasing selectivity over hERG.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.20 | 5.75 |
| IC25 | 6 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL214432 | — | — | 1 | 5.75 |
| CHEMBL216821 | — | — | 1 | 5.75 |
| CHEMBL215278 | — | — | 1 | 5.58 |
| CHEMBL424895 | — | — | 1 | 5.30 |
| CHEMBL217820 | — | — | 1 | 5.29 |
| CHEMBL215660 | — | — | 1 | 5.28 |
| CHEMBL437728 | — | — | 1 | 5.17 |
| CHEMBL216314 | — | — | 1 | 5.00 |
| CHEMBL216741 | — | — | 1 | 4.85 |
| CHEMBL216406 | — | — | 1 | 4.70 |
| CHEMBL267320 | — | — | 1 | 4.52 |
| CHEMBL217860 | — | — | 1 | - |
| CHEMBL214178 | — | — | 1 | - |
| CHEMBL213771 | — | — | 1 | - |
| CHEMBL268848 | — | — | 1 | - |
| CHEMBL217501 | — | — | 1 | - |
| CHEMBL216429 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL214432 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL216821 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL215278 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL424895 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL217820 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL215660 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL437728 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL216314 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL216741 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL216406 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL267320 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL217860 | — | IC25 | = | 2.5 | uM | - |
| CHEMBL214178 | — | IC25 | = | 7.6 | uM | - |
| CHEMBL213771 | — | IC25 | = | 14.0 | uM | - |
| CHEMBL268848 | — | IC25 | = | 20.0 | uM | - |
| CHEMBL217501 | — | IC25 | = | 30.0 | uM | - |
| CHEMBL216429 | — | IC25 | = | 34.0 | uM | - |