Assay Detail
Binding
CHEMBL854904
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Inhibition of 125I-MCH binding to human MCH-R1 expressed in CHO cell membranes
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Melanin-concentrating hormone receptor 1 (CHEMBL344) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of tetralin ureas as potent melanin concentrating hormone 1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 7.17 | 9.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361215 | — | — | 1 | 9.01 |
| CHEMBL205285 | — | — | 1 | 8.57 |
| CHEMBL216820 | — | — | 1 | 8.40 |
| CHEMBL217574 | — | — | 1 | 8.22 |
| CHEMBL384701 | — | — | 1 | 8.07 |
| CHEMBL191393 | — | — | 1 | 8.05 |
| CHEMBL385011 | — | — | 1 | 7.96 |
| CHEMBL216460 | — | — | 1 | 7.21 |
| CHEMBL216286 | — | — | 1 | 7.04 |
| CHEMBL216267 | — | — | 1 | 7.02 |
| CHEMBL386487 | — | — | 1 | 6.80 |
| CHEMBL216209 | — | — | 1 | 6.75 |
| CHEMBL217182 | — | — | 1 | 6.72 |
| CHEMBL426339 | — | — | 1 | 6.58 |
| CHEMBL216066 | — | — | 1 | 6.47 |
| CHEMBL217430 | — | — | 1 | 6.42 |
| CHEMBL217114 | — | — | 1 | 5.89 |
| CHEMBL217618 | — | — | 1 | 5.52 |
| CHEMBL217080 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361215 | — | Ki | = | 0.98 | nM | 9.01 |
| CHEMBL205285 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL216820 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL217574 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL384701 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL191393 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL385011 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL216460 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL216286 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL216267 | — | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL386487 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL216209 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL217182 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL426339 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL216066 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL217430 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL217114 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL217618 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL217080 | — | Ki | = | 3000.0 | nM | 5.52 |