Assay Detail
Binding
CHEMBL854909
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Displacement of 125I-MCH from MCH-R1 expressed in IMR-32 cells
10
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | IMR-32 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Melanin-concentrating hormone receptor 1 (CHEMBL344) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Constrained 7-fluorocarboxychromone-4-aminopiperidine based Melanin-concentrating hormone receptor 1 antagonists: the effects of chirality on substituted indan-1-ylamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.71 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL214585 | — | — | 3 | 9.00 |
| CHEMBL215661 | — | — | 3 | 8.52 |
| CHEMBL214731 | — | — | 1 | 8.40 |
| CHEMBL384111 | — | — | 1 | 7.96 |
| CHEMBL384919 | — | — | 1 | 7.68 |
| CHEMBL425257 | — | — | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL214585 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL215661 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL214731 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL215661 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL214585 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL384111 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL384919 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL425257 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL214585 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL215661 | — | IC50 | = | 2570.0 | nM | 5.59 |