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Assay Detail

CHEMBL854953

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Functional
Inhibition of A549 cell migration by microdroplet migration assay
ChEMBL ↗
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A549
Confidence 1 — Organism
Curated By Expert

Target

A549 (CHEMBL392) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor.
Hennequin LF, Allen J, Breed J, Curwen J, Fennell M, Green TP, Lambert-van der Brempt C, Morgentin R, Norman RA, Olivier A, Otterbein L, Plé PA, Warin N, Costello G.
J Med Chem (2006) 49 : 6465 -6488
PubMed 17064066 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 33 6.60 7.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL217463 — — 1 7.16
CHEMBL200217 — — 1 7.10
CHEMBL217464 — — 1 7.05
CHEMBL436968 — — 1 7.00
CHEMBL217092 SARACATINIB 3.0 1 6.85
CHEMBL214665 — — 1 6.82
CHEMBL217090 — — 1 6.82
CHEMBL217091 — — 1 6.82
CHEMBL214376 — — 1 6.82
CHEMBL216693 — — 1 6.70
CHEMBL213762 — — 1 6.70
CHEMBL386996 — — 1 6.54
CHEMBL262371 — — 1 6.52
CHEMBL216105 — — 1 6.52
CHEMBL385563 — — 1 6.52
CHEMBL385240 — — 1 6.52
CHEMBL381206 — — 1 6.40
CHEMBL426161 AZM-475271 2.0 1 6.32
CHEMBL215682 — — 1 6.30
CHEMBL384031 — — 1 6.16
CHEMBL387093 — — 1 5.92
CHEMBL217493 — — 1 5.60
CHEMBL386584 — — 1 -
CHEMBL263947 — — 1 -
CHEMBL439182 — — 1 -
CHEMBL266188 — — 1 -
CHEMBL385958 — — 1 -
CHEMBL262721 — — 1 -
CHEMBL384260 — — 1 -
CHEMBL214893 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL217463 — IC50 = 70.0 nM 7.16
CHEMBL200217 — IC50 = 80.0 nM 7.10
CHEMBL217464 — IC50 = 90.0 nM 7.05
CHEMBL436968 — IC50 = 100.0 nM 7.00
CHEMBL217092 SARACATINIB IC50 = 140.0 nM 6.85
CHEMBL214665 — IC50 = 150.0 nM 6.82
CHEMBL217090 — IC50 = 150.0 nM 6.82
CHEMBL217091 — IC50 = 150.0 nM 6.82
CHEMBL214376 — IC50 = 150.0 nM 6.82
CHEMBL216693 — IC50 = 200.0 nM 6.70
CHEMBL213762 — IC50 = 200.0 nM 6.70
CHEMBL386996 — IC50 = 290.0 nM 6.54
CHEMBL385240 — IC50 = 300.0 nM 6.52
CHEMBL385563 — IC50 = 300.0 nM 6.52
CHEMBL216105 — IC50 = 300.0 nM 6.52
CHEMBL262371 — IC50 = 300.0 nM 6.52
CHEMBL381206 — IC50 = 400.0 nM 6.40
CHEMBL426161 AZM-475271 IC50 = 480.0 nM 6.32
CHEMBL215682 — IC50 = 500.0 nM 6.30
CHEMBL384031 — IC50 = 700.0 nM 6.16
CHEMBL387093 — IC50 = 1200.0 nM 5.92
CHEMBL217493 — IC50 = 2500.0 nM 5.60
CHEMBL386584 — IC50 - — -
CHEMBL263947 — IC50 - — -
CHEMBL439182 — IC50 - — -
CHEMBL266188 — IC50 - — -
CHEMBL385958 — IC50 - — -
CHEMBL262721 — IC50 - — -
CHEMBL384260 — IC50 - — -
CHEMBL214893 — IC50 - — -
CHEMBL216703 — IC50 - — -
CHEMBL275513 — IC50 - — -
CHEMBL385533 — IC50 - — -