Assay Detail
Functional
CHEMBL855010
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Antiproliferative activity against human PC3 cells after 72 hrs
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and structure-activity relationships of carbazole sulfonamides as a novel class of antimitotic agents against solid tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.17 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.55 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 8.00 |
| CHEMBL216879 | — | — | 1 | 7.05 |
| CHEMBL216767 | — | — | 1 | 6.94 |
| CHEMBL385606 | — | — | 1 | 6.84 |
| CHEMBL437336 | — | — | 1 | 6.70 |
| CHEMBL216846 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL61 | PODOFILOX | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL216879 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL216767 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL385606 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL437336 | — | IC50 | = | 201.0 | nM | 6.70 |
| CHEMBL216846 | — | IC50 | = | 780.0 | nM | 6.11 |