Assay Detail
Binding
CHEMBL855015
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Inhibitory concentration against CD45 protein-tyrosine phosphatase using lck-10 mer as substrate
15
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Receptor-type tyrosine-protein phosphatase C (CHEMBL3243) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potent reversible inhibitors of the protein tyrosine phosphatase CD45.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.39 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51776 | — | — | 2 | 6.52 |
| CHEMBL50627 | — | — | 2 | 5.51 |
| CHEMBL51314 | — | — | 2 | 5.42 |
| CHEMBL38066 | — | — | 1 | 5.35 |
| CHEMBL50846 | — | — | 1 | 5.28 |
| CHEMBL51317 | — | — | 1 | 5.24 |
| CHEMBL53966 | — | — | 1 | 4.96 |
| CHEMBL50878 | — | — | 2 | 4.96 |
| CHEMBL299374 | — | — | 1 | - |
| CHEMBL300664 | — | — | 1 | - |
| CHEMBL51039 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51776 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL51776 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL50627 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL50627 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL51314 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL51314 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL38066 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL50846 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL51317 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL53966 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL50878 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL50878 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL299374 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL300664 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL51039 | — | IC50 | > | 30000.0 | nM | - |