Assay Detail
Binding
CHEMBL855020
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]histamine from human histamine H4 receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.36 | 7.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1533310 | HISTAMINE DIHYDROCHLORIDE | 4.0 | 1 | 7.90 |
| CHEMBL557151 | — | — | 1 | 7.50 |
| CHEMBL534494 | — | — | 1 | 6.60 |
| CHEMBL2311029 | — | — | 1 | 6.50 |
| CHEMBL539343 | — | — | 1 | 6.40 |
| CHEMBL534498 | — | — | 1 | 5.50 |
| CHEMBL535387 | — | — | 1 | 5.40 |
| CHEMBL534496 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1533310 | HISTAMINE DIHYDROCHLORIDE | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL557151 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL534494 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL2311029 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL539343 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL534498 | — | Ki | = | 3162.28 | nM | 5.50 |
| CHEMBL535387 | — | Ki | = | 3981.07 | nM | 5.40 |
| CHEMBL534496 | — | Ki | = | 7943.28 | nM | 5.10 |