Assay Detail
Functional
CHEMBL855046
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Antiproliferative activity against multidrug resistant MDA435/LCC6 cells in presence of 5 uM verapamil by ELISA
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-435 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Flavonoid dimers as bivalent modulators for P-glycoprotein-based multidrug resistance: synthetic apigenin homodimers linked with defined-length poly(ethylene glycol) spacers increase drug retention and enhance chemosensitivity in resistant cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.11 | 9.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 9.54 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.28 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.52 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | - |
| CHEMBL178 | DAUNORUBICIN | 4.0 | 1 | - |
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL90555 | VINCRISTINE | IC50 | - | — | - | |
| CHEMBL178 | DAUNORUBICIN | IC50 | - | — | - | |
| CHEMBL58 | MITOXANTRONE | IC50 | - | — | - |