Assay Detail
Binding
CHEMBL855227
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Inhibitory concentration against MCH1R IMR32 cells in FLIPR-based assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | IMR-32 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Melanin-concentrating hormone receptor 1 (CHEMBL344) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of ortho-amino benzamides and nicotinamides as MCHr1 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.12 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL196277 | — | — | 1 | 8.10 |
| CHEMBL196681 | — | — | 1 | 8.05 |
| CHEMBL194697 | — | — | 1 | 7.80 |
| CHEMBL194731 | — | — | 1 | 7.70 |
| CHEMBL194583 | — | — | 1 | 7.70 |
| CHEMBL371700 | — | — | 1 | 7.70 |
| CHEMBL193576 | — | — | 1 | 7.70 |
| CHEMBL195511 | — | — | 1 | 7.52 |
| CHEMBL194759 | — | — | 1 | 7.52 |
| CHEMBL365788 | — | — | 1 | 7.52 |
| CHEMBL434934 | — | — | 1 | 7.52 |
| CHEMBL194726 | — | — | 1 | 7.40 |
| CHEMBL371129 | — | — | 1 | 7.40 |
| CHEMBL364522 | — | — | 1 | 7.30 |
| CHEMBL363169 | — | — | 1 | 7.30 |
| CHEMBL196223 | — | — | 1 | 7.22 |
| CHEMBL373266 | — | — | 1 | 7.16 |
| CHEMBL274254 | — | — | 1 | 7.16 |
| CHEMBL365360 | — | — | 1 | 7.16 |
| CHEMBL195255 | — | — | 1 | 7.05 |
| CHEMBL373235 | — | — | 1 | 7.00 |
| CHEMBL365734 | — | — | 1 | 7.00 |
| CHEMBL196898 | — | — | 1 | 6.70 |
| CHEMBL194342 | — | — | 1 | 6.66 |
| CHEMBL194531 | — | — | 1 | 6.62 |
| CHEMBL196620 | — | — | 1 | 6.43 |
| CHEMBL427542 | — | — | 1 | 6.43 |
| CHEMBL196591 | — | — | 1 | 6.29 |
| CHEMBL195435 | — | — | 1 | 5.97 |
| CHEMBL193489 | — | — | 1 | 5.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL196277 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL196681 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL194697 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL194731 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL194583 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL371700 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL193576 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL195511 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL194759 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL365788 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL434934 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL194726 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL371129 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL364522 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL363169 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL196223 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL373266 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL274254 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL365360 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL195255 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL373235 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL365734 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL196898 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL194342 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL194531 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL196620 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL427542 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL196591 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL195435 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL193489 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL196168 | — | IC50 | = | 1940.0 | nM | 5.71 |