Assay Detail
Binding
CHEMBL855269
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]NOC from human ORL1 receptor expressed in HEK293 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and receptor binding properties of chimeric peptides containing a mu-opioid receptor ligand and nociceptin/orphanin FQ receptor ligand Ac-RYYRIK-amide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 9.32 | 10.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL414736 | — | — | 1 | 10.33 |
| CHEMBL441930 | — | — | 1 | 10.10 |
| CHEMBL437723 | — | — | 1 | 9.12 |
| CHEMBL412939 | — | — | 1 | 9.10 |
| CHEMBL404792 | — | — | 1 | 7.94 |
| CHEMBL278789 | DERMORPHIN | — | 1 | - |
| CHEMBL215513 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL414736 | — | IC50 | = | 0.0464 | nM | 10.33 |
| CHEMBL441930 | — | IC50 | = | 0.0803 | nM | 10.10 |
| CHEMBL437723 | — | IC50 | = | 0.767 | nM | 9.12 |
| CHEMBL412939 | — | IC50 | = | 0.789 | nM | 9.10 |
| CHEMBL404792 | — | IC50 | = | 11.6 | nM | 7.94 |
| CHEMBL278789 | DERMORPHIN | IC50 | > | 10000.0 | nM | - |
| CHEMBL215513 | — | IC50 | > | 10000.0 | nM | - |