Assay Detail
Binding
CHEMBL855418
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H](R)-QNB binding to human M1/M5(o2o3) chimeric receptor expressed in A9 L cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A9L |
| Confidence | 7 — Homologous single protein target |
| Curated By | Expert |
Target
Muscarinic acetylcholine receptor M1/M5 chimeric protein (CHEMBL2111417) ↗| Type | CHIMERIC PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of novel derivatives of the muscarinic agonist tetra(ethylene glycol)(3-methoxy-1,2,5-thiadiazol-4-yl) [3-(1-methyl-1,2,5,6-tetrahydropyrid-3-yl)-1,2,5-thiadiazol-4-yl] ether (CDD-0304): effects of structural modifications on the binding and activity at muscarinic receptor subtypes and chimeras.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.90 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL335542 | — | — | 1 | 7.00 |
| CHEMBL216927 | — | — | 1 | 6.50 |
| CHEMBL21536 | XANOMELINE | 4.0 | 1 | 5.90 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 4.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL335542 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL216927 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL21536 | XANOMELINE | Ki | = | 1258.93 | nM | 5.90 |
| CHEMBL14 | CARBACHOL | Ki | = | 63095.73 | nM | 4.20 |