Assay Detail
Functional
CHEMBL855502
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Antiproliferative activity against human K562 cell line
33
Total Activities
33
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as novel antimicrotubule agents-synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 6.38 | 9.00 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL378544 | VINBLASTINE SULFATE | 4.0 | 1 | 9.00 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.00 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.70 |
| CHEMBL219102 | — | — | 1 | 7.30 |
| CHEMBL219439 | — | — | 1 | 7.10 |
| CHEMBL218923 | — | — | 1 | 7.00 |
| CHEMBL441863 | — | — | 1 | 6.64 |
| CHEMBL376511 | — | — | 1 | 6.64 |
| CHEMBL373414 | — | — | 1 | 6.62 |
| CHEMBL437521 | — | — | 1 | 6.60 |
| CHEMBL375624 | — | — | 1 | 6.60 |
| CHEMBL218866 | — | — | 1 | 6.57 |
| CHEMBL374139 | — | — | 1 | 6.50 |
| CHEMBL219064 | — | — | 1 | 6.48 |
| CHEMBL218824 | — | — | 1 | 6.41 |
| CHEMBL216099 | — | — | 1 | 6.38 |
| CHEMBL376853 | — | — | 1 | 6.36 |
| CHEMBL219100 | — | — | 1 | 6.22 |
| CHEMBL425978 | — | — | 1 | 6.14 |
| CHEMBL219353 | — | — | 1 | 6.14 |
| CHEMBL218867 | — | — | 1 | 6.09 |
| CHEMBL218921 | — | — | 1 | 6.05 |
| CHEMBL219180 | — | — | 1 | 5.62 |
| CHEMBL374924 | — | — | 1 | 5.50 |
| CHEMBL219525 | — | — | 1 | 5.28 |
| CHEMBL374109 | — | — | 1 | 5.17 |
| CHEMBL219751 | — | — | 1 | 5.16 |
| CHEMBL218920 | — | — | 1 | 5.05 |
| CHEMBL216150 | — | — | 1 | 4.82 |
| CHEMBL374466 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL378544 | VINBLASTINE SULFATE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL107 | COLCHICINE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL219102 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL219439 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL218923 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL441863 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL376511 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL373414 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL437521 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL375624 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL218866 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL374139 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL219064 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL218824 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL216099 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL376853 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL219100 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL425978 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL219353 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL218867 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL218921 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL219180 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL374924 | — | IC50 | = | 3130.0 | nM | 5.50 |
| CHEMBL219525 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL374109 | — | IC50 | = | 6690.0 | nM | 5.17 |
| CHEMBL219751 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL218920 | — | IC50 | = | 8950.0 | nM | 5.05 |
| CHEMBL216150 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL374466 | — | IC50 | > | 90000.0 | nM | - |
| CHEMBL9514 | NOCODAZOLE | Activity | - | — | - | |
| CHEMBL427056 | — | IC50 | > | 90000.0 | nM | - |
| CHEMBL61 | PODOFILOX | IC50 | - | — | - |