Assay Detail
Functional
CHEMBL855596
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reversal of paclitaxel resistance in multidrug resistant MDA435/LCC6 cells by MTS assay
7
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-435 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Flavonoid dimers as bivalent modulators for P-glycoprotein-based multidrug resistance: synthetic apigenin homodimers linked with defined-length poly(ethylene glycol) spacers increase drug retention and enhance chemosensitivity in resistant cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.00 | 8.36 |
| EC50 | 3 | 6.11 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL214738 | — | — | 2 | 8.36 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 2 | 8.28 |
| CHEMBL216136 | — | — | 1 | 7.70 |
| CHEMBL215017 | — | — | 1 | 7.67 |
| CHEMBL217387 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL214738 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL216136 | — | IC50 | = | 19.9 | nM | 7.70 |
| CHEMBL215017 | — | IC50 | = | 21.5 | nM | 7.67 |
| CHEMBL6966 | VERAPAMIL | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL214738 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL217387 | — | EC50 | > | 10000.0 | nM | - |