Assay Detail
Functional
CHEMBL855600
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reversal of vinblastine resistance in multidrug resistant MDA435/LCC6 cells by MTS assay
5
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-435 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Flavonoid dimers as bivalent modulators for P-glycoprotein-based multidrug resistance: synthetic apigenin homodimers linked with defined-length poly(ethylene glycol) spacers increase drug retention and enhance chemosensitivity in resistant cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 9.33 | 9.60 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 9.60 |
| CHEMBL214738 | — | — | 2 | 9.44 |
| CHEMBL216136 | — | — | 1 | 9.21 |
| CHEMBL215017 | — | — | 1 | 9.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6966 | VERAPAMIL | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL214738 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL216136 | — | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL215017 | — | IC50 | = | 0.87 | nM | 9.06 |
| CHEMBL214738 | — | Activity | - | — | - |