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Assay Detail

CHEMBL855650

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Functional
Antimalarial activity against Plasmodium falciparum W2
ChEMBL ↗
59
Total Activities
59
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Intermediate

Target

Plasmodium falciparum (CHEMBL364) ↗
Type ORGANISM
Organism Plasmodium falciparum

Publication

In vitro and in vivo efficacy and in vitro metabolism of 1-phenyl-3-aryl-2-propen-1-ones against Plasmodium falciparum.
Gutteridge CE, Nichols DA, Curtis SM, Thota DS, Vo JV, Gerena L, Montip G, Asher CO, Diaz DS, Ditusa CA, Smith KS, Bhattacharjee AK.
Bioorg Med Chem Lett (2006) 16 : 5682 -5686
PubMed 16908136 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 59 5.50 6.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL383993 — — 1 6.64
CHEMBL76 CHLOROQUINE 4.0 1 6.62
CHEMBL221740 — — 1 6.30
CHEMBL220878 — — 1 6.23
CHEMBL218337 — — 1 6.17
CHEMBL218681 — — 1 6.10
CHEMBL218496 — — 1 6.02
CHEMBL221235 — — 1 5.96
CHEMBL218548 — — 1 5.96
CHEMBL375848 — — 1 5.92
CHEMBL218689 — — 1 5.89
CHEMBL221581 — — 1 5.82
CHEMBL385113 — — 1 5.80
CHEMBL218332 — — 1 5.77
CHEMBL138710 — — 1 5.70
CHEMBL218335 — — 1 5.66
CHEMBL218436 — — 1 5.57
CHEMBL218050 — — 1 5.57
CHEMBL374279 — — 1 5.55
CHEMBL341729 — — 1 5.55
CHEMBL218333 — — 1 5.51
CHEMBL220481 — — 1 5.51
CHEMBL220877 — — 1 5.50
CHEMBL218153 — — 1 5.48
CHEMBL138524 — — 1 5.48
CHEMBL221234 — — 1 5.48
CHEMBL137817 — — 1 5.48
CHEMBL218495 — — 1 5.39
CHEMBL218329 — — 1 5.37
CHEMBL434563 — — 1 5.37

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL383993 — IC50 = 230.0 nM 6.64
CHEMBL76 CHLOROQUINE IC50 = 240.0 nM 6.62
CHEMBL221740 — IC50 = 500.0 nM 6.30
CHEMBL220878 — IC50 = 590.0 nM 6.23
CHEMBL218337 — IC50 = 670.0 nM 6.17
CHEMBL218681 — IC50 = 800.0 nM 6.10
CHEMBL218496 — IC50 = 950.0 nM 6.02
CHEMBL221235 — IC50 = 1100.0 nM 5.96
CHEMBL218548 — IC50 = 1100.0 nM 5.96
CHEMBL375848 — IC50 = 1200.0 nM 5.92
CHEMBL218689 — IC50 = 1300.0 nM 5.89
CHEMBL221581 — IC50 = 1500.0 nM 5.82
CHEMBL385113 — IC50 = 1600.0 nM 5.80
CHEMBL218332 — IC50 = 1700.0 nM 5.77
CHEMBL138710 — IC50 = 2000.0 nM 5.70
CHEMBL218335 — IC50 = 2200.0 nM 5.66
CHEMBL218436 — IC50 = 2700.0 nM 5.57
CHEMBL218050 — IC50 = 2700.0 nM 5.57
CHEMBL374279 — IC50 = 2800.0 nM 5.55
CHEMBL341729 — IC50 = 2800.0 nM 5.55
CHEMBL218333 — IC50 = 3100.0 nM 5.51
CHEMBL220481 — IC50 = 3100.0 nM 5.51
CHEMBL220877 — IC50 = 3200.0 nM 5.50
CHEMBL137817 — IC50 = 3300.0 nM 5.48
CHEMBL221234 — IC50 = 3300.0 nM 5.48
CHEMBL218153 — IC50 = 3300.0 nM 5.48
CHEMBL138524 — IC50 = 3300.0 nM 5.48
CHEMBL218495 — IC50 = 4100.0 nM 5.39
CHEMBL218329 — IC50 = 4300.0 nM 5.37
CHEMBL434563 — IC50 = 4300.0 nM 5.37
CHEMBL221531 — IC50 = 4500.0 nM 5.35
CHEMBL139856 — IC50 = 4600.0 nM 5.34
CHEMBL426212 — IC50 = 4800.0 nM 5.32
CHEMBL441861 — IC50 = 5000.0 nM 5.30
CHEMBL383878 — IC50 = 5000.0 nM 5.30
CHEMBL218048 — IC50 = 5300.0 nM 5.28
CHEMBL221967 — IC50 = 5700.0 nM 5.24
CHEMBL218330 — IC50 = 5800.0 nM 5.24
CHEMBL218739 — IC50 = 5700.0 nM 5.24
CHEMBL221966 — IC50 = 5800.0 nM 5.24
CHEMBL220818 — IC50 = 6000.0 nM 5.22
CHEMBL375071 — IC50 = 6200.0 nM 5.21
CHEMBL218284 — IC50 = 6200.0 nM 5.21
CHEMBL218630 — IC50 = 6300.0 nM 5.20
CHEMBL218437 — IC50 = 7300.0 nM 5.14
CHEMBL217931 — IC50 = 7700.0 nM 5.11
CHEMBL218385 — IC50 = 7800.0 nM 5.11
CHEMBL218438 — IC50 = 8600.0 nM 5.07
CHEMBL220930 — IC50 = 9500.0 nM 5.02
CHEMBL139805 — IC50 = 10000.0 nM 5.00