Assay Detail
Binding
CHEMBL855663
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Inhibition of human EGLN1
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of a series of novel pyrazolopyridines as HIF-1alpha prolyl hydroxylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.75 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222115 | — | — | 1 | 6.72 |
| CHEMBL221012 | — | — | 1 | 6.24 |
| CHEMBL426560 | — | — | 1 | 5.85 |
| CHEMBL218070 | — | — | 1 | 5.80 |
| CHEMBL269093 | — | — | 1 | 5.80 |
| CHEMBL221241 | — | — | 1 | 5.77 |
| CHEMBL221013 | — | — | 1 | 5.77 |
| CHEMBL218424 | — | — | 1 | 5.68 |
| CHEMBL222114 | — | — | 1 | 5.62 |
| CHEMBL375008 | — | — | 1 | 5.62 |
| CHEMBL221189 | — | — | 1 | 5.57 |
| CHEMBL374147 | — | — | 1 | 5.55 |
| CHEMBL386421 | — | — | 1 | 5.54 |
| CHEMBL220743 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222115 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL221012 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL426560 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL218070 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL269093 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL221241 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL221013 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL218424 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL222114 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL375008 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL221189 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL374147 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL386421 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL220743 | — | IC50 | = | 12000.0 | nM | 4.92 |