Assay Detail
Binding
CHEMBL855666
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of POP in pig brain
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
An introduction of a pyridine group into the structure of prolyl oligopeptidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.12 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL375794 | — | — | 1 | 8.92 |
| CHEMBL221914 | — | — | 1 | 8.82 |
| CHEMBL221127 | — | — | 1 | 8.68 |
| CHEMBL220608 | — | — | 1 | 8.66 |
| CHEMBL289651 | — | — | 1 | 8.66 |
| CHEMBL434580 | — | — | 1 | 8.32 |
| CHEMBL374582 | — | — | 1 | 8.28 |
| CHEMBL189463 | — | — | 1 | 8.05 |
| CHEMBL375522 | — | — | 1 | 8.01 |
| CHEMBL218474 | — | — | 1 | 7.89 |
| CHEMBL375523 | — | — | 1 | 7.72 |
| CHEMBL218743 | — | — | 1 | 7.62 |
| CHEMBL425102 | — | — | 1 | 7.52 |
| CHEMBL217938 | — | — | 1 | 7.36 |
| CHEMBL217934 | — | — | 1 | 7.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL375794 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL221914 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL221127 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL220608 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL289651 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL434580 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL374582 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL189463 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL375522 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL218474 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL375523 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL218743 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL425102 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL217938 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL217934 | — | IC50 | = | 56.0 | nM | 7.25 |