Assay Detail
Binding
CHEMBL855891
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of (+/-)-[125I]DOI from human cloned 5HT2A receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
1-Aminomethylbenzocycloalkanes: conformationally restricted hallucinogenic phenethylamine analogues as functionally selective 5-HT2A receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.05 | 9.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL379637 | — | — | 1 | 9.46 |
| CHEMBL292821 | — | — | 1 | 9.18 |
| CHEMBL212197 | — | — | 1 | 9.14 |
| CHEMBL215781 | — | — | 1 | 7.82 |
| CHEMBL424890 | — | — | 1 | 7.28 |
| CHEMBL213612 | — | — | 1 | 6.77 |
| CHEMBL214379 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL379637 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL292821 | — | Ki | = | 0.66 | nM | 9.18 |
| CHEMBL212197 | — | Ki | = | 0.73 | nM | 9.14 |
| CHEMBL215781 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL424890 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL213612 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL214379 | — | Ki | = | 200.0 | nM | 6.70 |