Assay Detail
Toxicity
CHEMBL855968
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of hERG potassium channel
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.33 | 4.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL438992 | — | — | 1 | 4.43 |
| CHEMBL375745 | — | — | 1 | 4.23 |
| CHEMBL216835 | — | — | 1 | - |
| CHEMBL375442 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL438992 | — | IC50 | = | 36700.0 | nM | 4.43 |
| CHEMBL375745 | — | IC50 | = | 58500.0 | nM | 4.23 |
| CHEMBL216835 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL375442 | — | IC50 | > | 100000.0 | nM | - |