Assay Detail
Binding
CHEMBL855991
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Inhibition of human 11beta-HSD1
18
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
11-beta-hydroxysteroid dehydrogenase 1 (CHEMBL4235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and structural activity relationship of 11beta-HSD1 inhibitors with novel adamantane replacements.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.33 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL219448 | — | — | 1 | 8.30 |
| CHEMBL219295 | — | — | 1 | 7.96 |
| CHEMBL219606 | — | — | 1 | 7.89 |
| CHEMBL3085038 | — | — | 1 | 7.82 |
| CHEMBL386315 | — | — | 1 | 7.66 |
| CHEMBL218247 | — | — | 1 | 7.64 |
| CHEMBL375743 | — | — | 1 | 7.62 |
| CHEMBL376272 | — | — | 1 | 7.60 |
| CHEMBL374409 | — | — | 1 | 7.36 |
| CHEMBL387010 | — | — | 1 | 7.27 |
| CHEMBL219403 | — | — | 2 | 7.21 |
| CHEMBL218246 | — | — | 1 | 7.18 |
| CHEMBL384426 | — | — | 1 | 7.06 |
| CHEMBL216783 | — | — | 1 | 7.01 |
| CHEMBL386947 | — | — | 1 | 6.83 |
| CHEMBL384692 | — | — | 1 | 6.57 |
| CHEMBL387424 | — | — | 1 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL219448 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL219295 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL219606 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3085038 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL386315 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL218247 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL375743 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL376272 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL374409 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL387010 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL219403 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL218246 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL384426 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL216783 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL386947 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL219403 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL384692 | — | IC50 | = | 269.0 | nM | 6.57 |
| CHEMBL387424 | — | IC50 | = | 587.0 | nM | 6.23 |