Assay Detail
Binding
CHEMBL855994
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Inhibition of mouse 11beta-HSD1
18
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
11-beta-hydroxysteroid dehydrogenase 1 (CHEMBL3910) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Synthesis and structural activity relationship of 11beta-HSD1 inhibitors with novel adamantane replacements.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.75 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL219448 | — | — | 1 | 8.52 |
| CHEMBL376272 | — | — | 1 | 7.64 |
| CHEMBL3085038 | — | — | 1 | 7.62 |
| CHEMBL219295 | — | — | 1 | 7.55 |
| CHEMBL219606 | — | — | 1 | 7.55 |
| CHEMBL386315 | — | — | 1 | 7.50 |
| CHEMBL219403 | — | — | 2 | 7.21 |
| CHEMBL375743 | — | — | 1 | 6.92 |
| CHEMBL386947 | — | — | 1 | 6.79 |
| CHEMBL387010 | — | — | 1 | 6.65 |
| CHEMBL374409 | — | — | 1 | 5.94 |
| CHEMBL218247 | — | — | 1 | 5.70 |
| CHEMBL384426 | — | — | 1 | 5.40 |
| CHEMBL218246 | — | — | 1 | 5.32 |
| CHEMBL216783 | — | — | 1 | - |
| CHEMBL387424 | — | — | 1 | - |
| CHEMBL384692 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL219448 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL376272 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3085038 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL219295 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL219606 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL386315 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL219403 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL375743 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL386947 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL387010 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL374409 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL218247 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL384426 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL218246 | — | IC50 | = | 4780.0 | nM | 5.32 |
| CHEMBL219403 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL216783 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL387424 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL384692 | — | IC50 | > | 10000.0 | nM | - |